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Of the significantly altered genes, the top 25 downregulated and upregulated genes in metformin treated SW837 cells are demonstrated in Figures 5B, C

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Xia et al

Furthermore, studies have demonstrated that HFLS exert tumor-like cellular behaviors, such as abnormal proliferation, migration/invasion into the blood and joints, as well as generation of inflammatory cytokines, which mainly contribute to synovial inflammation and persistent bone damage, thereby exacerbating the progression of RA (62, 63)

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